5 HTP and Vitamin B6: Side Effects and Dangers

5-HTP is a natural and potent supplement that can help in fighting against certain mood disorders and abnormalities of sleep. How about 5-htp with vitamin b6, are there any danger or side effects?

5 htp with vitamin b6 danger

5-hydroxytryptophan, simply called 5-HTP, is a natural and potent supplement that can aid individuals in terms of helping them fight against certain mood disorders and abnormalities of sleep. 5-HTP is also produced naturally in the human brain and body and forms the process of producing serotonin, a neurotransmitter, through the metabolism of L-Tryptophan.

Most people will usually be aware that L-Tryptophan can promote the feeling of being sleepy if taken in significant amounts. In contrast, 5-HTP will generally not make patients sleepy but instead will help in calming the brain without the feeling of being sedated.

5-HTP is also found in certain species of plants such as Griffonia Simplicifolia which is the source of most supplements considered or identified as a nootropic. Some of the more common benefits of 5-HTP are enhanced weight loss, pain relief from fibromyalgia, prevention of neurodegeneration, mood enhancement, migraine or headache treatment, promotion of deep or sound sleep, reduced tension, anxiolytic benefits, and relaxation. Research also suggests that 5-HTP is an effective alternative to other pharmaceutical products that are used as antidepressants. This is a significant benefit for patients as 5-HTP will have fewer side effects and reduced addiction risk compared to other chemically or artificially produced products. Considering all these health benefits from 5-HTP, it is not surprising then that people may want to take this natural supplement to boost relaxation and rest.

The question is “ What does the combination of 5-HTP and Vitamin B6 Bring to the table?”.

What can combination supplementation of 5-HTP and Vitamin B6 do for patients?

These two (2) combination supplements, 5-HTP, and Vitamin B6, actually complement each other well and provide certain health benefits to those who will use them appropriately. First, Vitamin B6 has been known to increase the efficiency of = 5-HTP production in the brain. As such, taking Vitamin B6 supplements can help elevate the levels of= 5-HTP in the human brain. In addition, research suggests that people with a deficiency of  5-HTP may suffer from various malfunctions for a number of cognitive processes.

Reduced levels of Vitamin B6 have been observed in people who frequently drink alcohol or alcoholic drinks. These decreased levels of the said vitamins may lead to depression, abnormalities in blood pressure, sleeping problems or disorders, neuropathy, and a host of other adverse health conditions. Naturally, people are advised to limit their intake of alcohol to ensure that levels of vitamin B6 are maintained.

How do Vitamin B6 and 5-HTP promote patient relaxation?

As stated earlier in the article, 5-HTP is considered as a nootropic drug or a smart drug that can modify the neurochemistry make up of patients certain psychological and physiological health benefits which include feelings of improved wellbeing and enhanced mood. In physiological aspects, 5-HTP can easily penetrate the barrier between the blood and the brain which can then be converted into serotonin, a form of neurotransmitter that is primarily responsible for the promotion of tranquility and calmness. As such, medical professionals will normally not prescribe 5-HTP supplements to people who are already taking medication for serotonin level modification. Through the enhanced levels of serotonin, 5-HTP may be able to aid individuals in the treatment of certain disorders of mood and sleep.

It is important to remember then, that taking Vitamin B6 is important to help the body and the brain to converts its 5-HTP into serotonin.

What is the recommended dosage of 5-HTP and Vitamin B6?

The appropriate dosage of this combination supplementation will largely depend on the desired outcome the patient is after. For example, people who may want to address pains caused by fibromyalgia may require less 5-HTP dosage than some who want to treat their migraines and obesity. Some of the recommended doses are as follows:

  • Fibromyalgia pains- 100 milligrams 5 HTP with 10 Milligrams of Vitamin B6 three times a day
  • Migraine and headaches- 200 to 600 milligrams 5-HTP with 25 milligrams of Vitamin B6 once a day
  • Obesity- 600 to 900 milligrams 5-HTP with 25 milligrams of vitamin B6 not going beyond 12 weeks
  • Improved Sleep- 300 to 400 Milfligrams 5-HTP with 50 milligrams of vitamin B6 consumed right before going to bed
  • Relaxation and Anxiety 200 to 300 milligrams 5-HTP with 25 Milligrams of Vitamin B6 consumed daily even on an empty stomach.


What are the possible side effects of 5-HTP?

Patients who take in 5-HTP supplementation may experience stomach pain, vomiting, diarrhea, and nausea. These adverse effects will all depend on the dosage of the said supplement. This means that when the dosage is increased, the side effects will also likely increase. Patients are then advised to limit their initial 5-HTP dosage to just 50 to 100 milligrams twice a day before increasing the dosage based on the desired result.

There are also other forms of medication that may increase the production of serotonin and if combined with 5-HTP may increase levels of serotonin to dangerously high levels within the body. This condition is known as serotonin syndrome and is considered a condition that is life-threatening.

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